Mississippi County is a county located in the U.S. state of Arkansas. As of the most recent data available, the county has a population of approximately 51,979 people, with a population density of about 57.88 persons per square mile.
The county spans a total land area of 898.00 square miles (2,326.00 square kilometers). The administrative center and county seat is , which often serves as a hub for local governance and services. The largest city within the county by population is Blytheville.
Geographically, Mississippi County experiences varied elevations, with its highest point at Blytheville 256 ft and its lowest point at Wilson 0 ft. The region operates in the UTC-6.