Matherville is a village located in Mercer County, in the state of Illinois (IL), United States. Nestled in the East North Central division of the Midwest region, it covers an area of 0.4 square miles (1.0 km²) and sits at an elevation of 750 ft. With a population of approximately 772 residents, Matherville offers a peaceful, rural atmosphere.
The town's population is composed of about 47.54% males and 52.46% females, and it has a population density of 979.49 people per square mile (764.28/km²). Matherville lies at a latitude of 41.26 and a longitude of -90.61, operating in the UTC-6.
Locals reflect a blend of American ancestry, with roots primarily in United States (14.1%), followed by English (10.6%), German (16.7%), and Scotch-Irish (0%) heritage. The town is identified by the ZIP code 61263.