Derma is a town located in Calhoun County, in the state of Mississippi (MS), United States. Nestled in the East South Central division of the South region, it covers an area of 1.1 square miles (3.0 km²) and sits at an elevation of 284 ft. With a population of approximately 1,023 residents, Derma offers a peaceful, rural atmosphere.
The town's population is composed of about 44.48% males and 55.52% females, and it has a population density of 905.31 people per square mile (349.54/km²). Derma lies at a latitude of 33.86 and a longitude of -89.29, operating in the UTC-6.
Locals reflect a blend of American ancestry, with roots primarily in United States (19%), followed by English (1.3%), German (2.2%), and Scotch-Irish (0%) heritage. The town is identified by the ZIP code N/A.