Desoto County is a county located in the U.S. state of Mississippi. As of the most recent data available, the county has a population of approximately 107,199 people, with a population density of about 224.27 persons per square mile.
The county spans a total land area of 478.00 square miles (1,238.00 square kilometers). The administrative center and county seat is Hernando, which often serves as a hub for local governance and services. The largest city within the county by population is Southaven.
Geographically, Desoto County experiences varied elevations, with its highest point at Hernando 385 ft and its lowest point at Lynchburg 0 ft. The region operates in the UTC-6.