Isola is a town located in Humphreys County, in the state of Mississippi (MS), United States. Nestled in the East South Central division of the South region, it covers an area of 0.7 square miles (2.0 km²) and sits at an elevation of 116 ft. With a population of approximately 768 residents, Isola offers a peaceful, rural atmosphere.
The town's population is composed of about 46.61% males and 53.39% females, and it has a population density of 37.84 people per square mile (400.71/km²). Isola lies at a latitude of 33.26 and a longitude of -90.59, operating in the UTC-6.
Locals reflect a blend of American ancestry, with roots primarily in United States (8.6%), followed by English (0%), German (1.8%), and Scotch-Irish (1.8%) heritage. The town is identified by the ZIP code 38754.