Mayersville is a town located in Issaquena County, in the state of Mississippi (MS), United States. Nestled in the East South Central division of the South region, it covers an area of 1.1 square miles (3.0 km²) and sits at an elevation of 115 ft. With a population of approximately 795 residents, Mayersville offers a peaceful, rural atmosphere.
The town's population is composed of about 62.39% males and 37.61% females, and it has a population density of 709.82 people per square mile (274.06/km²). Mayersville lies at a latitude of 32.9 and a longitude of -91.05, operating in the UTC-6.