Itawamba County is a county located in the U.S. state of Mississippi. As of the most recent data available, the county has a population of approximately 22,770 people, with a population density of about 42.80 persons per square mile.
The county spans a total land area of 532.00 square miles (1,378.00 square kilometers). The administrative center and county seat is Fulton, which often serves as a hub for local governance and services. The largest city within the county by population is Fulton.
Geographically, Itawamba County experiences varied elevations, with its highest point at Mantachie 356 ft and its lowest point at Fulton 341 ft. The region operates in the UTC-6.