Prentiss is a town located in Jefferson Davis County, in the state of Mississippi (MS), United States. Nestled in the East South Central division of the South region, it covers an area of 1.9 square miles (5.0 km²) and sits at an elevation of 336 ft. With a population of approximately 1,158 residents, Prentiss offers a peaceful, rural atmosphere.
The town's population is composed of about 46.89% males and 53.11% females, and it has a population density of 619.25 people per square mile (239.09/km²). Prentiss lies at a latitude of 31.6 and a longitude of -89.87, operating in the UTC-6.
Locals reflect a blend of American ancestry, with roots primarily in United States (17.5%), followed by English (4%), German (2.2%), and Scotch-Irish (2.2%) heritage. The town is identified by the ZIP code 39474.