Prentiss County is a county located in the U.S. state of Mississippi. As of the most recent data available, the county has a population of approximately 25,556 people, with a population density of about 61.58 persons per square mile.
The county spans a total land area of 415.00 square miles (1,075.00 square kilometers). The administrative center and county seat is Booneville, which often serves as a hub for local governance and services. The largest city within the county by population is Booneville.
Geographically, Prentiss County experiences varied elevations, with its highest point at Jumpertown 589 ft and its lowest point at Marietta 382 ft. The region operates in the UTC-6.