Pemiscot County is a county located in the U.S. state of Missouri. As of the most recent data available, the county has a population of approximately 20,047 people, with a population density of about 40.66 persons per square mile.
The county spans a total land area of 493.00 square miles (1,277.00 square kilometers). The administrative center and county seat is Caruthersville, which often serves as a hub for local governance and services. The largest city within the county by population is Caruthersville.
Geographically, Pemiscot County experiences varied elevations, with its highest point at Caruthersville 282 ft and its lowest point at Holland 257 ft. The region operates in the UTC-6.