Holmes County is a county located in the U.S. state of Mississippi. As of the most recent data available, the county has a population of approximately 21,609 people, with a population density of about 28.58 persons per square mile.
The county spans a total land area of 756.00 square miles (1,958.00 square kilometers). The administrative center and county seat is Lexington, which often serves as a hub for local governance and services. The largest city within the county by population is Durant.
Geographically, Holmes County experiences varied elevations, with its highest point at Goodman 310 ft and its lowest point at Tchula 120 ft. The region operates in the UTC-6.