Pickens is a town located in Holmes County, in the state of Mississippi (MS), United States. Nestled in the East South Central division of the South region, it covers an area of 1.3 square miles (3.0 km²) and sits at an elevation of 232 ft. With a population of approximately 1,325 residents, Pickens offers a peaceful, rural atmosphere.
The town's population is composed of about 47.17% males and 52.83% females, and it has a population density of 60.00 people per square mile (409.27/km²). Pickens lies at a latitude of 32.89 and a longitude of -89.97, operating in the UTC-6.
Locals reflect a blend of American ancestry, with roots primarily in United States (4%), followed by English (0%), German (0%), and Scotch-Irish (0%) heritage. The town is identified by the ZIP code 39146.